Synthesis and antimycobacterial activity of some N1-[1-[3-aryl-1-(pyridin-2-, 3-, or 4-yl)-3-oxo]propyl]-2-pyridinecarboxamidrazones

被引：24

作者：

Mamolo, MG

Falagiani, V

Vio, L

Banfi, E

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] Univ Trieste, Dipartimento Sci Biomed, Sez Microbiol, I-34127 Trieste, Italy

来源：

FARMACO | 1999年 / 54卷 / 11-12期

关键词：

pyridine-2-carboxamidrazone; antimycobacterial activity;

D O I：

10.1016/S0014-827X(99)00097-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

N-1-[1-[3-aryl-1-(pyridin-2-,3-, and 4-yl)-3-oxo]propyl]-2-pyridinecarboxamidrazone derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis and a strain of Mycobacterium avium. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：761 / 767

页数：7

共 11 条

[1]

BANFI E, 1993, J CHEMOTHERAPY, V5, P164

[2]

Banfi E, 1991, J Chemother, V3 Suppl 1, P66

[3]

BAUER R, 1988, Z NATURFORSCH B, V43, P475

[4]

BUUHOIE NP, 1961, B SOC CHIM FR, P584

[5] INHIBITION OF MYELOPEROXIDASE RELEASE FROM RAT POLYMORPHONUCLEAR LEUKOCYTES BY A SERIES OF AZACHALCONE DERIVATIVES [J].

EDWARDS, ML ;

STEMERICK, DM ;

SABOL, JS ;

DIEKEMA, KA ;

DINERSTEIN, RJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (25) :4357-4362

[6]

HAWKINS JE, 1984, MYCOBACTERIA SOURC A, P177

[7]

MAMOLO MG, 1986, EUR J MED CHEM, V21, P467

[8]

Mamolo MG, 1996, FARMACO, V51, P65

[9]

MAMOLO MG, 1993, FARMACO, V48, P529

[10]

MAMOLO MG, 1992, FARMACO, V47, P1055

← 1 2 →