The role of hyperglycaemia and hyperinsulinaemia in causing vascular dysfunction in diabetes

被引:58
作者
King, GL
机构
[1] BRIGHAM & WOMENS HOSP, BOSTON, MA 02115 USA
[2] HARVARD UNIV, SCH MED, BOSTON, MA USA
关键词
growth factors; insulin resistance; protein kinase C; vascular cells;
D O I
10.3109/07853899608999103
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hyperglycaemia and insulin abnormality are the causes of all vascular diseases in diabetes. Recent studies have narrowed down the pathways by which hyperglycaemia can cause the various complications observed in the vasculature. Insulin resistance and hyperinsulinaemia have been associated with cardiovascular disease. New ideas are presented on how selective insulin resistance of the vasculature may be responsible for the increased incidence of hypertension and cardiovascular disease.
引用
收藏
页码:427 / 432
页数:6
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