Effect of oxytocin on growth hormone release in vitro

被引：11

作者：

Hulting, AL

Grenback, E

Pineda, J

Coya, R

Hokfelt, T

Meister, B

UvnasMoberg, K

机构：

[1] KAROLINSKA INST, DEPT NEUROSCI, S-17177 STOCKHOLM, SWEDEN

[2] KAROLINSKA HOSP, DEPT ENDOCRINOL, S-17176 STOCKHOLM, SWEDEN

[3] KAROLINSKA INST, DEPT PHARMACOL, S-17177 STOCKHOLM, SWEDEN

来源：

REGULATORY PEPTIDES | 1996年 / 67卷 / 02期

关键词：

anterior pituitary; oxytocin; oxytocin antagonist; growth hormone; galanin; cholecystokinin; rat;

D O I：

10.1016/S0167-0115(96)00112-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of oxytocin (OT) on growth hormone (GH) secretion was investigated using dispersed rat anterior pituitary cells. OT dose-dependently inhibited GH secretion as well as GHRH-stimulated GH release. The inhibitory actions of OT on GH release were totally abolished by pretreatment with the OT-antagonist VAP 259. The peptides galanin and cholecystokinin did not affect the OT-induced inhibition on basal or GHRH-stimulated GH release. Several possible mechanisms by which OT may influence GH release are discussed.

引用

页码：69 / 73

页数：5

共 42 条

[1] RAT OXYTOCIN RECEPTOR IN BRAIN, PITUITARY, MAMMARY-GLAND, AND UTERUS - PARTIAL SEQUENCE AND IMMUNOCYTOCHEMICAL LOCALIZATION [J].