Midodrine hydrochloride and the treatment of orthostatic hypotension in tetraplegia: two cases and a review of the literature

Study Design: A report of two cases of orthostatic hypotension in acute tetraplegia that were resistant to classic treatment interventions. Objective: To discuss the use of midodrine hydrochloride for the treatment of orthostatic hypotension in early tetraplegia. Setting: Department of Rehabilitation Medicine, The University of Texas Health Science Center at San Antonio, Texas, USA. Methods: Presentation of two cases. Results: Midodrine hydrochloride successfully treated two cases of orthostatic hypotension that had been refractory to classic treatment interventions. Conclusion: Midodrine hydrochloride should be included in the armamentarium of the physician treating orthostatic hypotension in spinal cord injury.