Substrate specificity of strictosidine synthase

被引：79

作者：

McCoy, E ^{[1
]}

Galan, MC ^{[1
]}

O'Connor, SE ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 09期

关键词：

alkaloids; biosynthesis; enzyme catalysis; glycosidase; Pictet-Spengler;

D O I：

10.1016/j.bmcl.2006.01.098

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Strictosidine synthase catalyzes a Pictet-Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway. (C) 2006 Elsevier Ltd. All rights reserved.

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页码：2475 / 2478

页数：4

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