Cell swelling activates STAT1 and STAT3 proteins in cultured rat hepatocytes

被引：9

作者：

Meisse, D

Dusanter-Fourt, I

Husson, A

Lavoinne, A

机构：

[1] Inst Federatif Rech Multidisciplinaire Peptides 2, Biochim & Physiopathol Digest & Nutr Grp, UFR Med Pharm Rouen, F-76183 Rouen, France

[2] Hop Cochin, ICGM, U363 INSERM, F-75014 Paris, France

来源：

FEBS LETTERS | 1999年 / 463卷 / 03期

关键词：

STAT protein; hypoosmolarity; alpha; 2-macroglobulin; interleukin-6; swelling; hepatocyte;

D O I：

10.1016/S0014-5793(99)01643-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper, se demonstrated that in cultured rat hepatocytes cell swelling induced the activation of STAT1 and STAT3 proteins without any effect on STAT4, STAT5 and STAT6 proteins, Cell swelling induced an activation of STAT proteins through an increase in the phosphorylation of the tyrosine residue also phosphorylated by interleukin-6, but without any activation of JAK kinases, The signaling pathway by which cell swelling activated STAT1 and STAT3 is discussed. (C) 1999 Federation of European Biochemical Societies.

引用

页码：360 / 364

页数：5

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