Detection of DCM-associated β1-adrenergic receptor autoantibodies requires functional readouts or native human β1-receptors as targets

被引:19
作者
Bornholz, Beatrice [1 ]
Hanzen, Birgit [1 ]
Reinke, Yvonne [2 ,3 ]
Felix, Stephan B. [2 ,3 ]
Jahns, Roland [4 ,5 ]
Schimke, Ingolf [6 ]
Wallukat, Gerd [6 ]
Boege, Fritz [1 ]
机构
[1] Univ Dusseldorf, Fac Med, Inst Clin Chem & Lab Diagnost, Dusseldorf, Germany
[2] Univ Med, Dept Internal Med B, Greifswald, Germany
[3] DZHK German Ctr Cardiovasc Res, Munich, Germany
[4] Univ Hosp Wurzburg, CHFC, Wurzburg, Germany
[5] Univ Hosp Wurzburg, Interdisciplinary Bank Biomat & Data Wurzburg Ibd, Wurzburg, Germany
[6] Berlin Cures GmbH, Berlin, Germany
关键词
Autoantibodies; Beta1-adrenergic receptor; Dilated cardiomyopathy; Diagnostic testing; Companion assay; Targeted therapy; PROTEIN-COUPLED RECEPTORS;
D O I
10.1016/j.ijcard.2015.10.068
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
[No abstract available]
引用
收藏
页码:728 / 730
页数:3
相关论文
共 10 条
[1]
Novel Receptor-Derived Cyclopeptides to Treat Heart Failure Caused by Anti-β1-Adrenoceptor Antibodies in a Human-Analogous Rat Model [J].
Boivin, Valerie ;
Beyersdorf, Niklas ;
Palm, Dieter ;
Nikolaev, Viacheslav O. ;
Schlipp, Angela ;
Mueller, Justus ;
Schmidt, Doris ;
Kocoski, Vladimir ;
Kerkau, Thomas ;
Huenig, Thomas ;
Ertl, Georg ;
Lohse, Martin J. ;
Jahns, Roland .
PLOS ONE, 2015, 10 (02)
[2]
A standardised FACS assay based on native, receptor transfected cells for the clinical diagnosis and monitoring of β1-adrenergic receptor autoantibodies in human heart disease [J].
Bornholz, Beatrice ;
Benninghaus, Thomas ;
Reinke, Yvonne ;
Felix, Stephan B. ;
Roggenbuck, Dirk ;
Jahns-Boivin, Valerie ;
Jahns, Roland ;
Boege, Fritz .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2016, 54 (04) :683-691
[3]
Diagnostic and therapeutic aspects of β1-adrenergic receptor autoantibodies in human heart disease [J].
Bornholz, Beatrice ;
Roggenbuck, Dirk ;
Jahns, Roland ;
Boege, Fritz .
AUTOIMMUNITY REVIEWS, 2014, 13 (09) :954-962
[4]
Impact of human autoantibodies on β1-adrenergic receptor conformation, activity, and internalization [J].
Bornholz, Beatrice ;
Weidtkamp-Peters, Stefanie ;
Schmitmeier, Stephanie ;
Seidel, Claus A. M. ;
Herda, Lars R. ;
Felix, Stephan B. ;
Lemoine, Horst ;
Hescheler, Juergen ;
Nguemo, Filomain ;
Schaefer, Christoph ;
Christensen, Morten O. ;
Mielke, Christian ;
Boege, Fritz .
CARDIOVASCULAR RESEARCH, 2013, 97 (03) :472-480
[5]
Immunoadsorption therapy for dilated cardiomyopathy and pulmonary arterial hypertension [J].
Dandel, Michael ;
Wallukat, Gerd ;
Englert, Angela ;
Hetzer, Roland .
ATHEROSCLEROSIS SUPPLEMENTS, 2013, 14 (01) :203-211
[6]
Neutralization of pathogenic beta1-receptor autoantibodies by aptamers in vivo: the first successful proof of principle in spontaneously hypertensive rats [J].
Haberland, Annekathrin ;
Wallukat, Gerd ;
Berg, Sabine ;
Schulz, Angela-Martina ;
Freyse, Ernst-Joachim ;
Vetter, Roland ;
Salzsieder, Eckhard ;
Mueller, Johannes ;
Kreutz, Reinhold ;
Schimke, Ingolf .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 393 (1-2) :177-180
[7]
Autoantibodies activating human β1-adrenergic receptors are associated with reduced cardiac function in chronic heart failure [J].
Jahns, R ;
Boivin, V ;
Siegmund, C ;
Inselmann, G ;
Lohse, MJ ;
Boege, F .
CIRCULATION, 1999, 99 (05) :649-654
[8]
Questionable Validity of Peptide-Based ELISA Strategies in the Diagnostics of Cardiopathogenic Autoantibodies That Activate G-Protein-Coupled Receptors [J].
Jahns, Roland ;
Boege, Fritz .
CARDIOLOGY, 2015, 131 (03) :149-150
[9]
Wallukat G, 2001, IN VITRO CELL DEV-AN, V37, P175
[10]
Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases [J].
Wallukat, Gerd ;
Schimke, Ingolf .
SEMINARS IN IMMUNOPATHOLOGY, 2014, 36 (03) :351-363