Human ABC transporter ABCG2 in xenobiotic protection and redox biology

被引：47

作者：

Wakabayashi, Kanako ^{[1
]}

Tamura, Ai ^{[1
]}

Saito, Hikaru ^{[1
]}

Onishi, Yuko ^{[1
]}

Ishikawa, Toshihisa ^{[1
]}

机构：

[1] Tokyo Inst Technol, Grad Sch Biosci & Biotechnol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

DRUG METABOLISM REVIEWS | 2006年 / 38卷 / 03期

关键词：

ABCG2; ABC transporter; BCRP; ER stress; oxidative stress; pheophorbide A; photodynamic therapy; photosensitivity; porphyria; porphyrin;

D O I：

10.1080/03602530600727947

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Human ATP-binding cassette (ABC) transporter ABCG2 (BCRP/MXR/ABCP) is regarded as a member of the phase III system of xenobiotic metabolism. This efflux pump is suggested to be responsible for protecting the body from toxic xenobiotics and for removing toxic metabolites. The aim of this review article is to address new aspects of ABCG2 related to redox biology, namely the posttranslational modification (intra- and intermolecular disulfide bond formation) of ABCG2 protein and the transport of porphyrin and chlorophyll metabolites, as well as the high-speed screening and QSAR analysis method to evaluate ABCG2-drug interactions.

引用

页码：371 / 391

页数：21

共 83 条

[1] Flavonoid structure-activity studies identify 6-prenyichrysin and tectochrysin as potent and specific inhibitors of breast cancer resistance protein ABCG2 [J].