Learning-memory deficit with aging in APP transgenic mice of Alzheimer's disease and intervention by using tetrahydroxystilbene glucoside

被引:108
作者
Zhang, Lan [1 ]
Xing, Ying [1 ]
Ye, Cui-Fei [1 ]
Ai, Hou-Xi [1 ]
Wei, Hai-Feng [1 ]
Li, Lin [1 ]
机构
[1] Capital Univ Med Sci, Xuanwu Hosp, Dept Pharmacol, Educ Minist Key Lab Neurodegenerat Dis, Beijing 100053, Peoples R China
基金
中国国家自然科学基金;
关键词
Alzheimer's disease (AD); PDAPPV717I transgenic mice; learning-memory ability; tetrahydroxystilbene glucoside; Polygonum multiflorum;
D O I
10.1016/j.bbr.2006.06.034
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Objective: To investigate learning-memory deficit in different ages of AD-like APP transgenic mice and to observe the protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (TSG), which is the main component of Polygonum multiflorum, on learning-memory abilities. Methods: PDAPPV717I transgenic (Tg) mice were randomly divided into 3 model groups (4, 10 and 16 months old mice) and TSG treated (at doses 120 and 240 mu mol/kg/d) groups. TSG was administered to some Tg mice with an age range 4-10 months. In untreated 10 months old Tg mice, the TSG was administrated to those falling in the age range 10-16 months. For the control group we adopted the same age and background C57BL/6J mice. The learning-memory ability was measured by applying Morris water maze (MWM) and object recognition test (ORT). Results: In the 4 months old PDAPPV717I Tg mice, the learning-memory deficit was detected. The escape latency in MWM was prolonged, and the discrimination index decreased in ORT. In the 10 months old Tg mice, the learning-memory deficit was aggravated. TSG improved all spatial learning-memory impairment in MWM as well as the object recognition impairment in ORT. In the 16 months old Tg mice, the learning-memory deficit remained to exist but abated a lot. TSG showed significant improvement in learning-memory ability in both MWM and ORT. Conclusion: PDAPPV717I transgenic mice with an age range 4-16 months revealed the existence of learning-memory deficit compared with the control group. Tetrahydroxystilbene glucoside not only prevents, i.e. at an early stage, the learning-memory deficit in AD-like model, but also can reverse the learning-memory deficit in the late stage of AD-like model. Thus, TSG could be considered among the future therapeutic drugs indicated for the treatment of AD. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:246 / 254
页数:9
相关论文
共 38 条
[1]  
[Anonymous], 2004, CHINESE J CLIN REHAB
[2]  
Bai Hai-bo, 2004, Zhongguo Zhong Yao Za Zhi, V29, P219
[3]  
Blalock EM, 2003, J NEUROSCI, V23, P3807
[4]   An evaluation of the implementation of case management in the community psychiatric nursing service [J].
Chan, S ;
Mackenzie, A ;
Ng, DTF ;
Leung, JKY .
JOURNAL OF ADVANCED NURSING, 2000, 31 (01) :144-156
[5]   A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease [J].
Chen, GQ ;
Chen, KS ;
Knox, J ;
Inglis, J ;
Bernard, A ;
Martin, SJ ;
Justice, A ;
McConlogue, L ;
Games, D ;
Freedman, SB ;
Morris, RGM .
NATURE, 2000, 408 (6815) :975-979
[6]   Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities [J].
Citron, M ;
Diehl, TS ;
Gordon, G ;
Biere, AL ;
Seubert, P ;
Selkoe, DJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (23) :13170-13175
[7]   Applications of the Morris water maze in the study of learning and memory [J].
D'Hooge, R ;
De Deyn, PP .
BRAIN RESEARCH REVIEWS, 2001, 36 (01) :60-90
[8]   Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1 [J].
Dewachter, I ;
Van Dorpe, J ;
Smeijers, L ;
Gilis, M ;
Kuipéri, C ;
Laenen, I ;
Caluwaerts, N ;
Moechars, D ;
Checler, DR ;
Vanderstichele, H ;
Van Leuven, F .
JOURNAL OF NEUROSCIENCE, 2000, 20 (17) :6452-6458
[9]   Modeling Alzheimer's disease in transgenic mice: effect of age and of Presenilin1 on amyloid biochemistry and pathology in APP/London mice [J].
Dewachter, I ;
van Dorpe, J ;
Spittaels, K ;
Tesseur, I ;
Van Den Haute, C ;
Moechars, D ;
Van Leuven, F .
EXPERIMENTAL GERONTOLOGY, 2000, 35 (6-7) :831-841
[10]   SEGREGATION OF A MISSENSE MUTATION IN THE AMYLOID PRECURSOR PROTEIN GENE WITH FAMILIAL ALZHEIMERS-DISEASE [J].
GOATE, A ;
CHARTIERHARLIN, MC ;
MULLAN, M ;
BROWN, J ;
CRAWFORD, F ;
FIDANI, L ;
GIUFFRA, L ;
HAYNES, A ;
IRVING, N ;
JAMES, L ;
MANT, R ;
NEWTON, P ;
ROOKE, K ;
ROQUES, P ;
TALBOT, C ;
PERICAKVANCE, M ;
ROSES, A ;
WILLIAMSON, R ;
ROSSOR, M ;
OWEN, M ;
HARDY, J .
NATURE, 1991, 349 (6311) :704-706