Ability of different rescue therapies to save the bowel in acute, severe, steroid-refractory ulcerative colitis

被引：27

作者：

Farkas, Klaudia ^{[1
]}

Molnar, Tamas ^{[1
]}

Szepes, Zoltan ^{[1
]}

机构：

[1] Univ Szeged, Dept Med 1, H-6720 Szeged, Hungary

来源：

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY | 2014年 / 8卷 / 06期

关键词：

acute ulcerative colitis; cyclosporine; infliximab; rescue therapy; tacrolimus; ORAL TACROLIMUS FK506; TERM-FOLLOW-UP; INTRAVENOUS CYCLOSPORINE; HOSPITALIZED-PATIENTS; CONTROLLED-TRIAL; SALVAGE THERAPY; DOUBLE-BLIND; INFLIXIMAB; COLECTOMY; MANAGEMENT;

D O I：

10.1586/17474124.2014.909726

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

To date, corticosteroids have been the primary therapies for acute, severe ulcerative colitis (UC). Patients not responding to intravenous steroids assessed at 3-5 days of the treatment are candidates for second-line rescue therapy. Cyclosporine (CsA), tacrolimus and infliximab (IFX) are also effective therapeutic options in acute, severe UC. In this review we summarized the results of the published studies examining and comparing the efficacy of CsA, tacrolimus and IFX as rescue therapies, and assessing the outcome of switching the drugs in case of therapeutic failure.

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收藏

页码：695 / 702

页数：8

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