A Drosophila model of Alzheimer's disease

被引：53

作者：

Crowther, Damian C. ^{[1
]}

Page, Richard ^{[1
]}

Chandraratna, Dhianjali ^{[1
]}

Lomas, David A. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med, CIMR Wellcome Trust, Cambridge CB2 2XY, England

来源：

AMYLOID, PRIONS, AND OTHER PROTEIN AGGREGATES, PT B | 2006年 / 412卷

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0076-6879(06)12015-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of a model of Alzheimer's disease in Drosophila allows us to identify and dissect pathological pathways using the most powerful genetic tools available to biology. By reconstructing essential steps in Alzheimer's pathology, such as amyloid beta peptide and tau overexpression, we can observe clear and rapid phenotypes that are surrogate markers for human disease. The characterization of progressive phenotypes by immunohistochemistry of the brain combined with longevity, climbing, and pseudopupil assays allows the investigator to generate quantitative data. Phenotypes may be modulated by changes in gene expression as part of a genetic screen or by potential therapeutic compounds.

引用

页码：234 / 255

页数：22

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