Chemoprevention of cancer

被引：387

作者：

Sporn, MB ^{[1
]}

Suh, N ^{[1
]}

机构：

[1] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Pharmacol, Hanover, NH 03755 USA

来源：

CARCINOGENESIS | 2000年 / 21卷 / 03期

关键词：

D O I：

10.1093/carcin/21.3.525

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to develop new chemo-preventive agents based on understanding of their mechanisms of action. Four classes of new agents, namely selective inhibitors of cyclooxygenase-2, selective estrogen receptor modulators, rexinoids (retinoids that bind selectively to the receptors known as RXRs) and ligands for the peroxisome proliferator-activated receptor-gamma are discussed in detail. The importance of developing totally new classes of chemopreventive agents is stressed, with particular emphasis on the potential usefulness of new synthetic triterpenoids derived from naturally occurring molecules.

引用

页码：525 / 530

页数：6

共 47 条

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