Distributions of p53 codon 72 polymorphism in primary open angle glaucoma

被引:49
作者
Lin, HJ
Chen, WC
Tsai, FJ
Tsai, SW
机构
[1] China Med Coll Hosp, Dept Med Genet & Pediat, Taichung 404, Taiwan
[2] China Med Coll, Dept Ophthalmol, Taichung, Taiwan
[3] China Med Coll, Dept Occupat Safety & Hlth, Taichung, Taiwan
[4] China Med Coll, Inst Environm Med, Taichung, Taiwan
关键词
D O I
10.1136/bjo.86.7.767
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Background: Glaucomatous neuropathy is a type of cell death by apoptosis. The p53 gene is one of the regulatory genes of apoptosis. Recently, p53 codon 72 polymorphism has been extensively studied to determine the risk factors responsible for many diseases. In the p53 gene, a single base change from G to C causes the alternation of amino acid residue 72 from arginine to proline. In this study the association between p53 codon 72 polymorphism and primary open angle glaucoma (POAG) patients was evaluated. Methods: 58 POAG patients and 59 healthy volunteers were enrolled in this study. Polymerase chain reaction based analysis was used to resolve the p53 codon 72 polymorphism. Results: There were significant differences in the distribution of the polymorphism between the control subjects and the POAG Patients (P = 0.00782) The praline form of p53 gene codon 72 appears to be a significant risk factor in the development of POAG (odds ratio 2.389, 95% confidence interval: 1.14 to 5.01). Conclusions: Retinal ganglion cells die during POAG by apoptosis. The tumour suppressor protein, p53, is one of the primary regulators steps of apoptosis, and the results of our study are compatible with this concept.
引用
收藏
页码:767 / 770
页数:4
相关论文
共 25 条
[1]   CODON-72 POLYMORPHISM OF THE TP53 GENE [J].
ARA, S ;
LEE, PSY ;
HANSEN, MF ;
SAYA, H .
NUCLEIC ACIDS RESEARCH, 1990, 18 (16) :4961-4961
[2]   Distributions of p53 codon 72 polymorphism in bladder cancer - proline form is prominent in invasive tumor [J].
Chen, WC ;
Tsai, FJ ;
Wu, JY ;
Wu, HC ;
Lu, HF ;
Li, CW .
UROLOGICAL RESEARCH, 2000, 28 (05) :293-296
[3]   High level expression of ΔN-p63:: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)? [J].
Crook, T ;
Nicholls, JM ;
Brooks, L ;
O'Nions, J ;
Allday, MJ .
ONCOGENE, 2000, 19 (30) :3439-3444
[4]   MULTIVARIATE-ANALYSIS IN GLAUCOMA - USE OF DISCRIMINANT-ANALYSIS IN PREDICTING GLAUCOMATOUS VISUAL-FIELD DAMAGE [J].
DRANCE, SM ;
SCHULZER, M ;
THOMAS, B ;
DOUGLAS, GR .
ARCHIVES OF OPHTHALMOLOGY, 1981, 99 (06) :1019-1022
[5]   DEFINITION OF A CONSENSUS BINDING-SITE FOR P53 [J].
ELDEIRY, WS ;
KERN, SE ;
PIETENPOL, JA ;
KINZLER, KW ;
VOGELSTEIN, B .
NATURE GENETICS, 1992, 1 (01) :45-49
[6]   ACCUMULATION OF NUCLEAR P53 AND TUMOR PROGRESSION IN BLADDER-CANCER [J].
ESRIG, D ;
ELMAJIAN, D ;
GROSHEN, S ;
FREEMAN, JA ;
STEIN, JP ;
CHEN, SC ;
NICHOLS, PW ;
SKINNER, DG ;
JONES, PA ;
COTE, RJ .
NEW ENGLAND JOURNAL OF MEDICINE, 1994, 331 (19) :1259-1264
[7]   APOPTOSIS IN ADULT RETINAL GANGLION-CELLS AFTER AXOTOMY [J].
GARCIAVALENZUELA, E ;
GORCZYCA, W ;
DARZYNKIEWICZ, Z ;
SHARMA, SC .
JOURNAL OF NEUROBIOLOGY, 1994, 25 (04) :431-438
[8]   PROGRAMMED CELL-DEATH OF RETINAL GANGLION-CELLS DURING EXPERIMENTAL GLAUCOMA [J].
GARCIAVALENZUELA, E ;
SHAREEF, S ;
WALSH, J ;
SHARMA, SC .
EXPERIMENTAL EYE RESEARCH, 1995, 61 (01) :33-44
[9]  
HARPER JW, 1993, CELL, V75, P805
[10]   P53 EXPRESSION IN OVARIAN BORDERLINE TUMORS AND STAGE-I CARCINOMAS [J].
KUPRYJANCZYK, J ;
BELL, DA ;
YANDELL, DW ;
SCULLY, RE ;
THOR, AD .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1994, 102 (05) :671-676