Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted

被引：98

作者：

Batovska, Daniela ^{[1
]}

Parushev, Stoyan ^{[1
]}

Stambohyska, Bistra ^{[1
]}

Tsvetkova, Iva ^{[2
]}

Ninova, Mariana ^{[2
]}

Najdenski, Hristo ^{[2
]}

机构：

[1] Bulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria

[2] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, BU-1113 Sofia, Bulgaria

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 05期

关键词：

Chalcones; Antibacterial activity; Staphylococcus aureus; Escherichia coli; SAR;

D O I：

10.1016/j.ejmech.2008.05.010

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4-chloro or 3',4',5'-trimethoxy groups. Their other ring B was variously substituted. It was found that the antistaphylococcal activity of chalcones was related to the energy difference between the two highest occupied molecular orbitals (HOMO and HOMO-1). Presence of hydroxyl group in ring B was not a determinant factor for the anti-staphylococcal activity, but the lipophilicity of ring A of the hydroxyl chalcones was of importance. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：2211 / 2218

页数：8

共 13 条

[1]

Combinatorial synthesis and antibacterial evaluation of an indexed chalcone library [J].

Ansari, FL ;

Nazir, S ;

Noureen, H ;

Mirza, B .

CHEMISTRY & BIODIVERSITY, 2005, 2 (12) :1656-1664

[2]

Study on the substituents' effects of a series of synthetic chalcones against the yeast Candida albicans [J].

Batovska, D. ;

Parushev, St. ;

Slavova, A. ;

Bankova, V. ;

Tsvetkova, I. ;

Ninova, M. ;

Najdenski, H. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (01) :87-92

[3]

Bowden K., 1990, J CHEM RES SYNOP, V12, P2801

[4]

A structure - Activity study of taxol, taxotere, and derivatives using the electronic indices methodology (EIM) [J].

Braga, SF ;

Galvao, DS .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2003, 43 (02) :699-706

[5]

Antimicrobial activity of flavonoids [J].

Cushnie, TPT ;

Lamb, AJ .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2005, 26 (05) :343-356

[6]

Dimmock JR, 1999, CURR MED CHEM, V6, P1125

[7]

FRISCH AMJ, 1998, GAUSSIAN 98 REVISION

[8]

Hindler J, 1992, CLIN MICROBIOLOGY PR

[9]

LAHTCHEV K, 2007, EUR J MED CHEM, DOI DOI 10.1016/J.EJMECH.2007.12.2007

[10]

Recent advances in therapeutic chalcones [J].

Ni, LM ;

Meng, CQ ;

Sikorski, JA .

EXPERT OPINION ON THERAPEUTIC PATENTS, 2004, 14 (12) :1669-1691

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