The biochemical basis of the health effects of exercise: an integrative view

被引：12

作者：

Booth, FW ^{[1
]}

Shanely, RA

机构：

[1] Univ Missouri, Dept Biomed Sci, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Med Pharmacol & Physiol, Columbia, MO 65211 USA

[3] Univ Missouri, Dalton Cardiovasc Inst, Columbia, MO 65211 USA

来源：

PROCEEDINGS OF THE NUTRITION SOCIETY | 2004年 / 63卷 / 02期

关键词：

gene-environment interaction; physical activity levels; sedentary lifestyle;

D O I：

10.1079/PNS2004337

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Physical inactivity-gene interactions result in changes in gene expression, leading to phenotypic changes in the skeletal muscle cell. A subpopulation of those genes that show changes in expression during physical inactivity are candidates for the environment-gene interactions that cross a threshold of biological significance such that overt clinical disease occurs. AMP kinase, GLUT4 and myosin heavy chain IIx are proposed as candidates for physical inactivity-modulated genes that have an altered function that may trigger a crossing of a threshold to disease. Future experiments will be needed to test the validity of the ideas presented.

引用

页码：199 / 203

页数：5

共 39 条

[1] Bed rest increases the amount of mismatched fibers in human skeletal muscle [J].

Andersen, JL ;

Gruschy-Knudsen, T ;

Sandri, C ;

Larsson, L ;

Schiaffino, S .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (02) :455-460

[2]

Astrand PO., 1986, TXB WORK PHYSL

[3]

Atha J, 1981, Exerc Sport Sci Rev, V9, P1

[4]

Beaudet A, 1995, METABOLIC MOL BASES, P53

[5] Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity [J].

Bey, L ;

Akunuri, N ;

Zhao, P ;

Hoffman, EP ;

Hamilton, DG ;

Hamilton, MT .

PHYSIOLOGICAL GENOMICS, 2003, 13 (02) :157-167

[6] Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy [J].

Booth, FW ;

Chakravarthy, MV ;

Gordon, SE ;

Spangenburg, EE .

JOURNAL OF APPLIED PHYSIOLOGY, 2002, 93 (01) :3-30

[7] Influence of complete spinal cord injury on skeletal muscle within 6 mo of injury [J].

Castro, MJ ;

Apple, DF ;

Staron, RS ;

Campos, GER ;

Dudley, GA .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (01) :350-358

[8]

CHAKRAVARTHY MV, 2003, EXERCISE

[9] TIME COURSE OF LOSS OF ADAPTATIONS AFTER STOPPING PROLONGED INTENSE ENDURANCE TRAINING [J].

COYLE, EF ;

MARTIN, WH ;

SINACORE, DR ;

JOYNER, MJ ;

HAGBERG, JM ;

HOLLOSZY, JO .

JOURNAL OF APPLIED PHYSIOLOGY, 1984, 57 (06) :1857-1864

[10]

Gregory CM, 2001, MUSCLE NERVE, V24, P387, DOI 10.1002/1097-4598(200103)24:3<387::AID-MUS1010>3.0.CO

← 1 2 3 4 →