Suppressive effect of polysaccharides from the edible and medicinal mushrooms, Lentinus edodes and Agaricus blazei, on the expression of cytochrome P450s in mice

被引：46

作者：

Hashimoto, T

Nonaka, Y

Minato, K

Kawakami, S

Mizuno, M

Fukuda, I

Kanazawa, K

Ashida, H

机构：

[1] Kobe Univ, Grad Sch Sci & Technol, Div Life Sci, Nada Ku, Kobe, Hyogo 6578501, Japan

[2] Kobe Univ, Dept Biofunct Chem, Fac Agr, Nada Ku, Kobe, Hyogo 6578501, Japan

[3] Miyagi Agr Coll, Taihaku Ku, Sendai, Miyagi 9820215, Japan

[4] Tottori Mycol Inst, Tottori 6891125, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2002年 / 66卷 / 07期

关键词：

lentinan; Lentinas edodes; Agaricus blazei polysaccharides; cytochrome P450; tumor necrosis factor-alpha (TNF-alpha);

D O I：

10.1271/bbb.66.1610

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

To investigate the effects of lentinan from Lentinas edodes and polysaccharides from Agaricus blazei (ABPS) on the expression of cytochrome P450s (CYPs), lentinan (10 mg/kg/day) or ABPS (200 mg/kg/day) was administered to female BALB/c mice four times every other day by intraperitoneal injection. Lentinan and ABPS suppressed both the constitutive and 3-methylcholanthrene-induced CYP1A expression and ethoxyresorufin-O-deethylation activity in the liver.

引用

页码：1610 / 1614

页数：5

共 22 条

[1]

ABDELRAZZAK Z, 1994, MOL PHARMACOL, V46, P1100

[2]

EFFECT OF LENTINAN AND MANNAN ON PHAGOCYTOSIS OF FLUORESCENT LATEX MICROBEADS BY MOUSE PERITONEAL-MACROPHAGES - A FLOW CYTOMETRIC STUDY [J].