Genome stability and the processing of damaged replication forks by RecG

被引：114

作者：

McGlynn, P ^{[1
]}

Lloyd, RG ^{[1
]}

机构：

[1] Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2UH, England

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 08期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0168-9525(02)02720-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromosomal duplication faces many blocks to replication fork progression that could destabilize the genome and prove fatal if not overcome. Overcoming such blocks requires interplay between DNA replication, recombination and repair. The Recta protein of Escherichia coli promotes rescue of damaged forks by catalysing their unwinding and conversion to Holliday junctions. Subsequent processing of this structure allows repair or bypass of the fork block, enabling replication to resume without recourse to potentially mutagenic translesion synthesis or recombination. Such direct rescue of stalled forks might help safeguard genome integrity in all organisms.

引用

页码：413 / 419

页数：7

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