Genetic loci affecting resistance to human malaria parasites in a West African mosquito vector population

被引：107

作者：

Niaré, O

Markianos, K

Volz, J

Oduol, F

Touré, A

Bagayoko, M

Sangaré, D

Traoré, SF

Wang, R

Blass, C

Dolo, G

Bouaré, M

Kafatos, FC

Kruglyak, L

Touré, YT

Vernick, KD

机构：

[1] NYU, Sch Med, Dept Med & Mol Parasitol, New York, NY 10010 USA

[2] Fac Med Pharm & Odontostomatol, Dept Epidemiol Affectat Parasitaires, Bamako, Mali

[3] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

[4] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

[5] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

SCIENCE | 2002年 / 298卷 / 5591期

关键词：

D O I：

10.1126/science.1073420

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Successful propagation of the malaria parasite Plasmodium falciparum within a susceptible mosquito vector is prerequisite for the transmission of malaria. A field-based genetic analysis of the major human malaria vector, Anopheles gambiae, has revealed natural factors that reduce the transmission of P. falciparum. Differences in P. falciparum oocyst numbers between mosquito isofemale families fed on the same infected blood indicated large genetic component affecting resistance to the parasite, and genome-wide scanning in pedigrees of wild mosquitoes detected segregating resistance alleles. The apparently high natural frequency of resistance alleles suggests that malaria parasites (or similar pathogen) exert significant selective pressure on vector populations.

引用

页码：213 / 216

页数：5

共 27 条

[1] Plasmodium falciparum sporozoites increase feeding-associated mortality of their mosquito hosts Anopheles gambiae s.l. [J].