X-ray structure of glial cell-derived neurotrophic factor at 1.9 angstrom resolution and implications for receptor binding

被引：100

作者：

Eigenbrot, C

Gerber, N

机构：

[1] Department of Protein Engineering, Genentech, Inc., San Francisco, CA 94080, 460 Pt. San Bruno Boulevard, South

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 06期

关键词：

D O I：

10.1038/nsb0697-435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.

引用

页码：435 / 438

页数：4

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