Hemospray treatment is effective for lower gastrointestinal bleeding

被引:40
作者
Holster, I. Lisanne [1 ]
Brullet, Enric [2 ,3 ]
Kuipers, Ernst J. [1 ]
Campo, Rafel [2 ,3 ]
Fernandez-Atutxa, Alberto [2 ,3 ]
Tjwa, Eric T. T. L. [1 ]
机构
[1] Erasmus MC Univ Med Ctr, Dept Gastroenterol & Hepatol, NL-3000 CA Rotterdam, Netherlands
[2] Corp Sanitaria Univ Parc Tauli, Hosp Sabadell, Dept Digest Dis, Sabadell, Spain
[3] Networked Biomed Res Ctr Hepat & Digest Dis CIBER, Galicia, Spain
关键词
HEMORRHAGE;
D O I
10.1055/s-0033-1344988
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Acute lower gastrointestinal bleeding (LGIB) is diverse in origin and can be substantial, requiring urgent hemostasis. Hemospray is a promising novel hemostatic agent for upper gastrointestinal bleeding (UGIB). It has been claimed in a small series that the use of Hemospray is also feasible in LGIB. We aimed to expand our knowledge of the application of Hemospray for the treatment of LGIB in a wider range of conditions to further define the optimal patient population for this new therapeutic modality. We analyzed the outcomes of nine unselected consecutive patients with active LGIB treated with Hemospray in two major hospitals in Europe. Initial hemostasis was achieved after Hemospray application in all patients. Rebleeding occurred in two patients (22%) who were on acetyl salicylic acid and presented with spurting bleeds. These preliminary data show that Hemospray can be effective in the management of LGIB, but suggest cautious use for patients on antithrombotic therapy and spurting bleeds.
引用
收藏
页码:75 / 78
页数:4
相关论文
共 7 条
[1]
Hemospray in the treatment of upper gastrointestinal hemorrhage in patients on antithrombotic therapy [J].
Holster, I. L. ;
Kuipers, E. J. ;
Tjwa, E. T. T. L. .
ENDOSCOPY, 2013, 45 (01) :63-66
[2]
Time Trends and Impact of Upper and Lower Gastrointestinal Bleeding and Perforation in Clinical Practice [J].
Lanas, Angel ;
Garcia-Rodriguez, Luis A. ;
Polo-Tomas, Monica ;
Ponce, Marta ;
Alonso-Abreu, Inmaculada ;
Angeles Perez-Aisa, Maria ;
Perez-Gisbert, Javier ;
Bujanda, Luis ;
Castro, Manuel ;
Munoz, Maria ;
Rodrigo, Luis ;
Calvet, Xavier ;
Del-Pino, Dolores ;
Garcia, Santiago .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2009, 104 (07) :1633-1641
[3]
Morris AJ, 2012, GASTROINTEST ENDOSC, V75, P133
[4]
Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients [J].
Schulman, S ;
Kearon, C .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (04) :692-694
[5]
Lower GI hemorrhage controlled with endoscopically applied TC-325 [J].
Soulellis, Constantine A. ;
Carpentier, Stephanie ;
Chen, Yen-I ;
Fallone, Carlo A. ;
Barkun, Alan N. .
GASTROINTESTINAL ENDOSCOPY, 2013, 77 (03) :504-507
[6]
Early clinical experience of the safety and effectiveness of Hemospray in achieving hemostasis in patients with acute peptic ulcer bleeding [J].
Sung, J. J. Y. ;
Luo, D. ;
Wu, J. C. Y. ;
Ching, J. Y. L. ;
Chan, F. K. L. ;
Lau, J. Y. W. ;
Mack, S. ;
Ducharme, R. ;
Okolo, P. ;
Canto, M. ;
Kalloo, A. ;
Giday, S. A. .
ENDOSCOPY, 2011, 43 (04) :291-295
[7]
Epidemiology of lower gastrointestinal bleeding [J].
Zuccaro, Gregory .
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY, 2008, 22 (02) :225-232