Neuroprotective effect of high-dose albumin therapy against global ischemic brain injury in rats

被引：70

作者：

Belayev, L ^{[1
]}

Saul, I ^{[1
]}

Huh, PW ^{[1
]}

Finotti, N ^{[1
]}

Zhao, WZ ^{[1
]}

Busto, R ^{[1
]}

Ginsberg, MD ^{[1
]}

机构：

[1] Univ Miami, Sch Med, Dept Neurol, Cerebral Vasc Dis Res Ctr, Miami, FL 33101 USA

来源：

BRAIN RESEARCH | 1999年 / 845卷 / 01期

关键词：

albumin; global cerebral ischemia; neuroprotection; stroke;

D O I：

10.1016/S0006-8993(99)01952-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (25% HSA) or vehicle (0.9% NaCl) was administered i.v. 5 min after termination of ischemia. HSA-treated rats showed significantly improved neurological deficits throughout a 7-day survival period. Histologically, HSA-treated rats showed 2.4- to 5.3-fold increases in numbers of surviving CA1 hippocampal pyramidal neurons compared to saline-treated animals. These results document that high-dose albumin therapy instituted 5 min after global ischemia significantly improves neurological score and reduces histological damage. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：107 / 111

页数：5

共 26 条

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