T lymphocyte subsets and Th1/Th2 balance after laparoscopy-assisted distal gastrectomy

被引：102

作者：

Fujii, K ^{[1
]}

Sonoda, K ^{[1
]}

Izumi, K ^{[1
]}

Shiraishi, N ^{[1
]}

Adachi, Y ^{[1
]}

Kitano, S ^{[1
]}

机构：

[1] Oita Med Univ, Dept Surg 1, Oita 8795593, Japan

来源：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2003年 / 17卷 / 09期

关键词：

gastric cancer; laparoscopic surgery; surgical stress; T lymphocyte subset; Th1/Th2; balance;

D O I：

10.1007/s00464-002-9149-3

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: Laparoscopic surgery provides for a less invasive procedure than open surgery in patients with gastric cancer, but the immune responses after laparoscopic surgery for early gastric cancer remain unknown. Methods: Peripheral blood mononuclear cells from 20 patients with early gastric cancer who underwent laparoscopy-assisted distal gastrectomy (LADG) or open distal gastrectomy (ODG) were obtained; the cell surface molecules and intracellular cytokines (IFN-gamma and IL-4) were measured by flow cytometry. Results: The populations of T lymphocytes after LADG, including CD3-, 4-, 8-, 57-, and HLA-DR-positive lymphocytes, showed patterns similar to those after ODG. The production of IFN-gamma as Th1 cell function decreased significantly on the third postoperative day after ODG but increased after LADG. The production of IL-4, representing Th2 cell function, increased postoperatively after ODG but not after LADG. Conclusions: When compared with ODG, LADG contributes to the preservation of postsurgical Th1 cell-mediated immune function.

引用

页码：1440 / 1444

页数：5

共 26 条

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