The role of NADPH oxidases in diabetic cardiomyopathy

被引：78

作者：

Hansen, Synne S. ^{[1
]}

Aasum, Ellen ^{[1
]}

Hafstad, Anne D. ^{[1
]}

机构：

[1] UIT Arctic Univ Tromso, Fac Hlth Sci, Dept Med Biol, Cardiovasc Res Grp, N-9037 Tromso, Norway

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2018年 / 1864卷 / 05期

关键词：

NADPH oxidases; Diabetic cardiomyopathy; Oxidative stress; Metabolism; Obesity and insulin resistance; OXYGEN SPECIES PRODUCTION; OXIDATIVE STRESS; MOUSE MODEL; CARDIAC DYSFUNCTION; NAD(P)H OXIDASE; HEART-FAILURE; UP-REGULATION; ACTIVATION; REDOX; NOX4;

D O I：

10.1016/j.bbadis.2017.07.025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte mediating both adaptive and maladaptive changes in the heart. NOXs have been suggested as a therapeutic target for several diabetic complications, but their role in diabetic cardiomyopathy is far from elucidated. In this review we aim to provide an overview of the current knowledge regarding the understanding of how NOXs influences cardiac adaptive and maladaptive processes in a "diabetic milieu". This article is part of a Special issue entitled Cardiac adaptations to obesity, diabetes and insulin resistance, edited by Professors Jan F.C. Glatz, Jason R.B. Dyck and Christine Des Rosiers.

引用

页码：1908 / 1913

页数：6

共 63 条

[1]

Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement [J].