Mesenchymal Stem Cell Homing: The Devil Is in the Details

被引：1146

作者：

Karp, Jeffrey M. ^{[1
,2
,3
]}

Teol, Grace Sock Leng ^{[1
,2
,3
,4
]}

机构：

[1] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[2] Brigham & Womens Hosp, Dept Med, HST Ctr Biomed Engn, Cambridge, MA 02139 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

[4] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore 639798, Singapore

来源：

CELL STEM CELL | 2009年 / 4卷 / 03期

关键词：

MARROW STROMAL CELLS; IMPROVES CARDIAC-PERFORMANCE; HUMAN BONE-MARROW; MYOCARDIAL-INFARCTION; PROGENITOR CELLS; ENDOTHELIAL-CELLS; P-SELECTIN; IN-VITRO; PROMOTING MIGRATION; MAGNETIC-RESONANCE;

D O I：

10.1016/j.stem.2009.02.001

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The study of MSC trafficking is clinically relevant for minimally invasive cell therapy to promote regeneration of damaged tissue, to treat inflammation, and to promote angiogenesis. However, these studies are complicated by the diverse methods used to culture, characterize, and deliver MSCs and by the variety of methods used to assess homing events. This review provides a critical analysis of the methods used to track homing of exogenously infused MSCs and discusses strategies for enhancing their trafficking to particular tissues.

引用

页码：206 / 216

页数：11

共 96 条

[1] THE INTEGRIN VLA-4 SUPPORTS TETHERING AND ROLLING IN FLOW ON VCAM-1
ALON, R
KASSNER, PD
CARR, MW
FINGER, EB
HEMLER, ME
SPRINGER, TA
[J]. JOURNAL OF CELL BIOLOGY, 1995, 128 (06) : 1243 - 1253
[2] Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation
Annabi, B
Lee, YT
Turcotte, S
Naud, E
Desrosiers, RR
Champagne, M
Eliopoulos, N
Galipeau, J
Béliveau, R
[J]. STEM CELLS, 2003, 21 (03) : 337 - 347
[3] Stem cell factor and mesenchymal and neural stem cell transplantation in a rat model of Huntington's disease
Bantubungi, Kadiombo
Blum, David
Cuvelier, Laetitia
Wislet-Gendebieni, Sabine
Rogister, Bernard
Brouillet, Emmanuel
Schiffmann, Serge N.
[J]. MOLECULAR AND CELLULAR NEUROSCIENCE, 2008, 37 (03) : 454 - 470
[4] Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium - Feasibility, cell migration, and body distribution
Barbash, IM
Chouraqui, P
Baron, J
Feinberg, MS
Etzion, S
Tessone, A
Miller, L
Guetta, E
Zipori, D
Kedes, LH
Kloner, RA
Leor, J
[J]. CIRCULATION, 2003, 108 (07) : 863 - 868
[5] Immunologic consequences of multiple, high-dose administration of allogeneic mesenchymal stem cells to baboons
Beggs, Kirstin J.
Lyubimov, Alex
Borneman, Jade N.
Bartholomew, Amelia
Moseley, Annemarie
Dodds, Robert
Archambault, Michael P.
Smith, Alan K.
McIntosh, Kevin R.
[J]. CELL TRANSPLANTATION, 2006, 15 (8-9) : 711 - 721
[6] Efficient homing of multipotent adult mesenchymal stem cells depends on FROUNT-mediated clustering of CCR2
Belema-Bedada, Fikru
Uchida, Shizuka
Martire, Alessandra
Kostin, Sawa
Braun, Thomas
[J]. CELL STEM CELL, 2008, 2 (06) : 566 - 575
[7] Homing of in vitro expanded Stro-1- or Stro-1+ human mesenchymal stem cells into the NOD/SCID mouse and their role in supporting human CD34 cell engraftment
Bensidhoum, M
Chapel, A
Francois, S
Demarquay, C
Mazurier, C
Fouillard, L
Bouchet, S
Bertho, JM
Gourmelon, P
Aigueperse, J
Charbord, P
Gorin, NC
Thierry, D
Lopez, M
[J]. BLOOD, 2004, 103 (09) : 3313 - 3319
[8] Mesenchymal stem cells: Revisiting history, concepts, and assays
Bianco, Paolo
Robey, Pamela Gehron
Simmons, Paul J.
[J]. CELL STEM CELL, 2008, 2 (04) : 313 - 319
[9] CXCR4-transgene expression significantly improves marrow engraftment of cultured hematopoietic stem cells
Brenner, S
Whiting-Theobald, N
Kawai, T
Linton, GF
Rudikoff, AG
Choi, U
Ryser, MF
Murphy, PM
Sechler, JMG
Malech, HL
[J]. STEM CELLS, 2004, 22 (07) : 1128 - 1133
[10] LEUKOCYTE-ENDOTHELIAL CELL RECOGNITION - 3 (OR MORE) STEPS TO SPECIFICITY AND DIVERSITY
BUTCHER, EC
[J]. CELL, 1991, 67 (06) : 1033 - 1036

← 1 2 3 4 5 6 7 8 9 10 →