Unusual antimicrobial compounds from Aeollanthus buchnerianus

被引:22
作者
Dellar, JE
Cole, MD
Waterman, PG
机构
[1] UNIV STRATHCLYDE,DEPT PHARMACEUT SCI,PHYTOCHEM RES LABS,GLASGOW G1 1XW,LANARK,SCOTLAND
[2] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,FORENS SCI UNIT,GLASGOW G1 1XW,LANARK,SCOTLAND
来源
EXPERIENTIA | 1996年 / 52卷 / 02期
关键词
Aeollanthus buchnerianus; Lamiaceae; dodecanoic acids; abietane diterpenes; antifungal and antibacterial bioactivity;
D O I
10.1007/BF01923365
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Using bioassay guided isolation, three novel 12 carbon polyoxygenated fatty acids and a novel abietane diterpene have been isolated from the the chloroform extract of aerial parts of Aeollanthus buchnerianus (Lamiaceae). Rigorous spectroscopic methods were used for compound identification. (Z,Z)-8 zeta-acetoxy-5 zeta-hydroxydodeca-2,6-dienoic acid and (Z,Z)-5 zeta,8 zeta-dihydroxydodeca-2,6-dienoic acid inhibited the spore germination of Cladosporium cucumerinum (both with Minimum Inhibitory Dose (MID) values of 1 mu g) and Aspergillus niger (MID 5 and 25 mu g respectively). Further, they also reduced the hyphal growth of Pythium ultimum. (Z)-5 zeta-hydroxy-6 zeta,7 zeta,8 zeta-triacetoxydodeca-2- dienoic acid exhibited short term inhibition of the growth of Cladosporium cucumerinum. The novel abietane diterpenoid, (rel)-14 alpha-acetoxyabiet-7-en-18-oic acid inhibited the growth of the gram positive bacteria Bacillus subtilis, Staphylococcus aureus and Streptomyces scabies (MIC values 80, 20 and 20 mu g ml(-1) respectively).
引用
收藏
页码:175 / 179
页数:5
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