Neuropsychological Decline in Frontotemporal Lobar Degeneration: A Longitudinal Analysis

被引:53
作者
Libon, David J. [1 ]
Xie, Sharon X. [2 ]
Wang, Xingmei [2 ]
Massimo, Lauren [3 ]
Moore, Peachie [3 ]
Vesely, Luisa [3 ]
Khan, Alea [3 ]
Chatterjee, Anjan [3 ]
Coslett, H. Branch [3 ]
Hurtig, Howard I. [3 ]
Liang, Tsao-Wei [4 ]
Grossman, Murray [3 ]
机构
[1] Drexel Univ, Coll Med, Dept Neurol, Philadelphia, PA 19129 USA
[2] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA
[4] Thomas Jefferson Univ Hosp, Dept Neurol, Philadelphia, PA 19107 USA
基金
美国国家卫生研究院;
关键词
frontotemporal dementia; Alzheimer's disease; longitudinal assessment; MENTAL-STATE-EXAMINATION; PRIMARY PROGRESSIVE APHASIA; ALZHEIMERS-DISEASE; CORTICOBASAL DEGENERATION; COGNITIVE CHANGE; WORK GROUP; DEMENTIA; MEMORY; MECHANISMS; CONSORTIUM;
D O I
10.1037/a0014995
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Few studies have assessed whether the patterns of neuropsychological impairment in patients with different frontotemporal lobar degeneration (FTLD) subtypes remain distinct over the duration of their illness or devolve into a common, undifferentiated neuropsychological state. A longitudinal neuropsychological analysis was obtained over 100 months assessing executive control, language/naming, and visuoconstruction in 441 patients diagnosed with Alzheimer's disease (AD) and four FTLD subtypes, i.e., a social comportment/dysexecutive (SOC/EXEC) disorder; progressive non-fluent aphasia (PNFA); semantic dementia (SemD); and corticobasal degeneration (CBD). Initial group differences on each measure were maintained over the duration of illness, including several double dissociations. For example, AD patients exhibited a decline in 'animal' fluency; PNFA patients had difficulty on tests of executive control, SemD maintained their impairment on tests of naming, and CBD had presented with performance on visuoconstructional tests. None of the group by neuropsychological task interactions evaluating longitudinal decline was significant, suggesting that performance does not converge onto a common subtype over time. These data indicate that distinct patterns of neuropsychological impairment are maintained longitudinally, reflecting the unique anatomic distribution of relative disease burden in AD and FTLD.
引用
收藏
页码:337 / 346
页数:10
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