The role of AMP-activated protein kinase in mitochondrial biogenesis

被引：295

作者：

Reznick, Richard M.

Shulman, Gerald I. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Internal Med, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Howard Hughes Med Inst, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2006年 / 574卷 / 01期

关键词：

D O I：

10.1113/jphysiol.2006.109512

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While it has been known for more than 75 years that physical activity is associated with increased mitochondrial content in muscle, the molecular mechanism for this adaptive process has only recently been elucidated. This brief review examines existing studies that have identified AMPK-activated protein kinase (AMPK) and several other key regulators of mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and -1 beta, calcium/calmodulin-dependent protein kinase IV, and nitric oxide. In addition, the potential role of mitochondrial dysfunction in the pathogenesis of insulin resistance associated with ageing and type 2 diabetes mellitus is also discussed.

引用

页码：33 / 39

页数：7

共 46 条

[1] Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice
Akimoto, T
Ribar, TJ
Williams, RS
Yan, Z
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2004, 287 (05): : C1311 - C1319
[2] Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
Atherton, PJ
Babraj, JA
Smith, K
Singh, J
Rennie, MJ
Wackerhage, H
[J]. FASEB JOURNAL, 2005, 19 (02) : 786 - +
[3] Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1
Baar, K
Wende, AR
Jones, TE
Marison, M
Nolte, LA
Chen, M
Kelly, DP
Holloszy, JO
[J]. FASEB JOURNAL, 2002, 16 (14) : 1879 - 1886
[4] MATERNALLY TRANSMITTED DIABETES AND DEAFNESS ASSOCIATED WITH A 10.4 KB MITOCHONDRIAL-DNA DELETION
BALLINGER, SW
SHOFFNER, JM
HEDAYA, EV
TROUNCE, I
POLAK, MA
KOONTZ, DA
WALLACE, DC
[J]. NATURE GENETICS, 1992, 1 (01) : 11 - 15
[5] Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis
Bergeron, R
Ren, JM
Cadman, KS
Moore, IK
Perret, P
Pypaert, M
Young, LH
Semenkovich, CF
Shulman, GI
[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2001, 281 (06): : E1340 - E1346
[6] TRANSCRIPTION AND REPLICATION OF ANIMAL MITOCHONDRIAL DNAS
CLAYTON, DA
[J]. INTERNATIONAL REVIEW OF CYTOLOGY-A SURVEY OF CELL BIOLOGY, 1992, 141 : 217 - 232
[7] Evidence and age-related distribution of mtDNA D-loop point mutations in skeletal muscle from healthy subjects and mitochondrial patients
Del Bo, R
Bordoni, A
Boneschi, FM
Crimi, M
Sciacco, M
Bresolin, N
Scarlato, G
Comi, GP
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2002, 202 (1-2) : 85 - 91
[8] Fink W J, 1977, Ann N Y Acad Sci, V301, P323
[9] ENZYME-ACTIVITY AND FIBER COMPOSITION IN SKELETAL-MUSCLE OF UNTRAINED AND TRAINED MEN
GOLLNICK, PD
SALTIN, B
SAUBERT, CW
ARMSTRONG, RB
PIEHL, K
[J]. JOURNAL OF APPLIED PHYSIOLOGY, 1972, 33 (03) : 312 - +
[10] AMP-activated protein kinase: A key system mediating metabolic responses to exercise
Hardie, DG
[J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2004, 36 (01) : 28 - 34

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