Proteophosphoglycan secreted by Leishmania mexicana amastigotes causes vacuole formation in macrophages

被引：47

作者：

Peters, C ^{[1
]}

Stierhof, YD ^{[1
]}

Ilg, T ^{[1
]}

机构：

[1] MAX PLANCK INST BIOL,ABT MEMBRANBIOCHEM,D-72076 TUBINGEN,GERMANY

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 02期

关键词：

D O I：

10.1128/IAI.65.2.783-786.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The amastigote form of leishmania mexicana parasites colonizes macrophage phagolysosomes and induces the enlargement of these compartments to form huge parasitophorous vacuoles. We report here that a purified secreted amastigote product, proteophosphoglycan, is a macromolecule which causes vacuolization of peritoneal macrophages in vitro. Secretion of this glycoconjugate by intracellular parasites may contribute to the expansion of phagolysosomal compartments in infected cells.

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页码：783 / 786

页数：4

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