Mitochondrial permeability transition pore: Back to the drawing board

被引：43

作者：

Chinopoulos, Christos ^{[1
,2
]}

机构：

[1] Semmelweis Univ, Dept Med Biochem, Tuzolto St 37-47, H-1094 Budapest, Hungary

[2] MTA SE Lendulet Neurobiochem Res Grp, Budapest, Hungary

来源：

NEUROCHEMISTRY INTERNATIONAL | 2018年 / 117卷

关键词：

c-subunit ring; ATP synthase; Dimers; Bioenergetics; F1FO ATP SYNTHASE; CA-2&-INDUCED MEMBRANE TRANSITION; ADENINE-NUCLEOTIDE TRANSLOCASE; C-SUBUNIT RING; CYCLOPHILIN-D; ARTEMIA-FRANCISCANA; CELL-DEATH; PROTEIN INTERACTIONS; UNCOUPLING CHANNEL; PHOSPHATE CARRIER;

D O I：

10.1016/j.neuint.2017.06.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Current models theorizing on what the mitochondrial permeability transition (mPT) pore is made of, implicate the c-subunit rings of ATP synthase complex. However, two very recent studies, one on atomistic simulations and in the other disrupting all genes coding for the c subunit disproved those models. As a consequence of this, the structural elements of the pore remain unknown. The purpose of the present short-review is to (i) briefly review the latest findings, (ii) serve as an index for more comprehensive reviews regarding mPT specifics, (iii) reiterate on the potential pitfalls while investigating mPT in conjunction to bioenergetics, and most importantly (iv) suggest to those in search of mPT pore identity, to also look elsewhere. (C) 2017 Elsevier Ltd. All rights reserved.

引用

收藏

页码：49 / 54

页数：6

相关论文

共 108 条

[1]

Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death [J].

Abramov, Andrey Y. ;

Fraley, Cresson ;

Diao, Catherine T. ;

Winkfein, Robert ;

Colicos, Michael A. ;

Duchen, Michael R. ;

French, Robert J. ;

Pavlov, Evgeny .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (46) :18091-18096

[2]

An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore [J].

Alavian, Kambiz N. ;

Beutner, Gisela ;

Lazrove, Emma ;

Sacchetti, Silvio ;

Park, Han-A ;

Licznerski, Pawel ;

Li, Hongmei ;

Nabili, Panah ;

Hockensmith, Kathryn ;

Graham, Morven ;

Porter, George A., Jr. ;

Jonas, Elizabeth A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (29) :10580-10585

[3]

A high-throughput screening for mammalian cell death effectors identifies the mitochondrial phosphate carrier as a regulator of cytochrome c release [J].

Alcala, S. ;

Klee, M. ;

Fernandez, J. ;

Fleischer, A. ;

Pimental-Muinos, Fx .

ONCOGENE, 2008, 27 (01) :44-54

[4]

Arrázola MS, 2015, METHODS MOL BIOL, V1254, P87, DOI 10.1007/978-1-4939-2152-2_7

[5]

Phosphorylation of a peptide related to subunit c of the F0F1-ATPase/ATP synthase and relationship to permeability transition pore opening in mitochondria [J].

Azarashvili, TS ;

Tyynelä, J ;

Odinokova, IV ;

Grigorjev, PA ;

Baumann, M ;

Evtodienko, YV ;

Saris, NEL .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 2002, 34 (04) :279-284

[6]

The mitochondrial permeability transition from yeast to mammals [J].

Azzolin, Luca ;

von Stockum, Sophia ;

Basso, Emy ;

Petronilli, Valeria ;

Forte, Michael A. ;

Bernardi, Paolo .

FEBS LETTERS, 2010, 584 (12) :2504-2509

[7]

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death [J].

Baines, CP ;

Kaiser, RA ;

Purcell, NH ;

Blair, NS ;

Osinska, H ;

Hambleton, MA ;

Brunskill, EW ;

Sayen, MR ;

Gottlieb, RA ;

Dorn, GW ;

Robbins, J ;

Molkentin, JD .

NATURE, 2005, 434 (7033) :658-662

[8]

Properties of the permeability transition pore in mitochondria devoid of cyclophilin D [J].

Basso, E ;

Fante, L ;

Fowlkes, J ;

Petronilli, V ;

Forte, MA ;

Bernardi, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (19) :18558-18561

[9]

Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation [J].

Basso, Emy ;

Petronilli, Valeria ;

Forte, Michael A. ;

Bernardi, Paolo .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (39) :26307-26311

[10]

Quantitative biochemical and ultrastructural comparison of mitochondrial permeability transition in isolated brain and liver mitochondria: Evidence for reduced sensitivity of brain mitochondria [J].

Berman, SB ;

Watkins, SC ;

Hastings, TG .

EXPERIMENTAL NEUROLOGY, 2000, 164 (02) :415-425

← 1 2 3 4 5 6 7 8 9 10 →