Aminocarbonylations of alkenyl phosphates, chlorides, bromides, and triflates with Mo(CO)6 as a solid CO source

被引：39

作者：

Lagerlund, Olof ^{[1
]}

Mantel, Mette L. H. ^{[1
]}

Larhed, Mats ^{[1
]}

机构：

[1] Uppsala Univ, Dept Med Chem, Uppsala Biomed Ctr, SE-75123 Uppsala, Sweden

来源：

TETRAHEDRON | 2009年 / 65卷 / 36期

基金：

瑞典研究理事会;

关键词：

Carbonylation; Microwave; Vinyl halides; Vinyl phosphates; Vinyl triflates; Alkenyl electrophiles; Palladium; Enolizable ketones; PALLADIUM-CATALYZED CARBONYLATION; MICROWAVE-PROMOTED AMINOCARBONYLATION; CARBON-MONOXIDE; ARYL CHLORIDES; CONVENIENT; SCOPE; AMIDATION; COUPLINGS; EXCHANGE; HALIDES;

D O I：

10.1016/j.tet.2009.06.101

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed aminocarbonylations of alkenyl chlorides, bromides, and triflates were investigated using Mo(CO)(6) as a solid carbon monoxide source. The reactions afforded moderate to good yields producing a wide variety of acrylamides after 20 min of microwave irradiation. In addition, the aminocarbonylation reaction was, for the first time, expanded to include alkenyl phosphates as starting materials. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：7646 / 7652

页数：7

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