The beta cell in autoimmune diabetes: Many mechanisms and pathways of loss

被引：53

作者：

Kay, TWH ^{[1
]}

Thomas, HE ^{[1
]}

Harrison, LC ^{[1
]}

Allison, J ^{[1
]}

机构：

[1] PO Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Autoimmun & Transplantat Div, Melbourne, Vic, Australia

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2000年 / 11卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S1043-2760(99)00210-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Death of pancreatic beta cells is the final step in the pathogenesis of type I diabetes before it becomes clinically apparent. Applying recent basic research about how cells die to rite clinical problem of diabetes is a current opportunity and challenge. To date, perforin is the only factor definitely implicated in beta-cell killing in the non-obese diabetic (NOD) mouse model, although some perforin-deficient NOD mice develop diabetes. Our results suggest that other factors that cause beta-cell death remain to be identified.

引用

页码：11 / 15

页数：5

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