Bone microdamage acid skeletal fragility in osteoporotic and stress fractures

被引:482
作者
Burr, DB
Forwood, MR
Fyhrie, DP
Martin, B
Schaffler, MB
Turner, CH
机构
[1] INDIANA UNIV,SCH MED,DEPT ORTHOPED SURG,INDIANAPOLIS,IN 46202
[2] INDIANA UNIV,SCH MED,BIOMECH & BIOMAT RES CTR,INDIANAPOLIS,IN 46202
[3] UNIV QUEENSLAND,DEPT ANAT SCI,BRISBANE,QLD,AUSTRALIA
[4] HENRY FORD HOSP,CTR BONE & JOINT,DETROIT,MI 48202
[5] UNIV CALIF DAVIS,DEPT ORTHOPED SURG,DAVIS,CA 95616
关键词
D O I
10.1359/jbmr.1997.12.1.6
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
The accumulation of bone microdamage has been proposed as one factor that contributes to increased skeletal fragility with age and that may increase the risk for fracture in older women. This paper reviews the current status and understanding of microdamage physiology and its importance to skeletal fragility. Several questions are addressed: Does microdamage exist in vivo in bone? If it does, does it impair bone quality? Does microdamage accumulate with age, and is the accumulation of damage with age sufficient to cause a fracture? The nature of the damage repair mechanism is reviewed, and it is proposed that osteoporotic fracture may be a consequence of a positive feedback between damage accumulation and the increased remodeling space associated with repair.
引用
收藏
页码:6 / 15
页数:10
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