Effect of Dexamethasone on Differentiation of Multipotent Stromal Cells from Human Adipose Tissue

被引：10

作者：

Arutyunyan, I. V. ^{[1
,2
]}

Rzhaninova, A. A. ^{[1
,2
]}

Volkov, A. V. ^{[1
,3
]}

Goldstein, D. V. ^{[1
,2
]}

机构：

[1] ReMeTex Co, Moscow, Russia

[2] Russian Acad Med Sci, Moscow Med Genet Res Ctr, Moscow, Russia

[3] Russian Acad Med Sci, Inst Human Morphol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 147卷 / 04期

关键词：

human adipose tissue multipotent stromal cells; osteogenesis; adipogenesis; dexamethasone; BONE-MARROW; GENE-EXPRESSION; RETINOIC ACID; PHENOTYPE;

D O I：

10.1007/s10517-009-0548-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Effect of dexamethasone on differentiation of multipotent stromal cells from human adipose tissue was evaluated. Addition of dexamethasone to growth medium resulted in active adipogenesis. Addition of dexamethasone to the osteogenic medium (containing active vitamin D3 form as the main inductor) led to simultaneous realization of the adipogenic and osteogenic potencies of multipotent stromal cells of the adipose tissue. Hence, the quality of the transplant on the basis of predifferentiated multipotent stromal cells from the adipose tissue for bone tissue repair can be deteriorated by dexamethasone directing some cells to adipogenic development.

引用

页码：503 / 508

页数：6

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