Automated ordering of fingerprinted clones

被引：9

作者：

Flibotte, S ^{[1
]}

Chiu, R ^{[1
]}

Fjell, C ^{[1
]}

Krzywinski, M ^{[1
]}

Schein, JE ^{[1
]}

Shin, H ^{[1
]}

Marra, MA ^{[1
]}

机构：

[1] British Columbia Canc Res Ctr, Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada

来源：

BIOINFORMATICS | 2004年 / 20卷 / 08期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1093/bioinformatics/bth079

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: A considerable amount of human intervention is currently required to produce high-quality fingerprint-based physical maps for genomic studies. Results: An algorithm has been developed and implemented to automatically order fingerprinted clones within contigs. The resulting software, named CORAL (Clone ORdering ALgorithm), has been tested on maps that have previously been manually edited and on maps derived from in silico simulations. The fingerprint map and DNA sequence of the human genome has provided an additional test to CORAL. Measurements suggest that CORAL performs significantly better than the software currently used by most laboratories to order fingerprinted clones at throughputs far exceeding those that can be achieved manually. s.

引用

页码：1264 / 1271

页数：8

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