Leydig-cell tumors caused by an activating mutation of the gene encoding the luteinizing hormone receptor.

被引:167
作者
Liu, G
Duranteau, L
Carel, J
Monroe, J
Doyle, DA
Shenker, A
机构
[1] Northwestern Univ, Dept Pediat, Div Endocrinol, Sch Med, Chicago, IL 60611 USA
[2] Childrens Mem Inst Educ & Res, Chicago, IL USA
[3] Grp Hosp Cochin St Vincent De Paul, Serv Endocrinol Pediat, Paris, France
[4] Temple Univ, Childrens Med Ctr, Div Pediat Endocrinol, Philadelphia, PA 19122 USA
关键词
D O I
10.1056/NEJM199912023412304
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:1731 / 1736
页数:6
相关论文
共 36 条
[1]   STRUCTURE OF THE HUMAN LUTEINIZING-HORMONE CHORIOGONADOTROPIN RECEPTOR GENE - UNUSUAL PROMOTER AND 5'-NONCODING-REGIONS [J].
ATGER, M ;
MISRAHI, M ;
SAR, S ;
LEFLEM, L ;
DESSEN, P ;
MILGROM, E .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1995, 111 (02) :113-123
[2]   Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations [J].
Chan, WY .
MOLECULAR GENETICS AND METABOLISM, 1998, 63 (02) :75-84
[3]   Leydig cell hyperplasia and adenoma formation: Mechanisms and relevance to humans [J].
Clegg, ED ;
Cook, JC ;
Chapin, RE ;
Foster, PMD ;
Foster, GP .
REPRODUCTIVE TOXICOLOGY, 1997, 11 (01) :107-121
[4]   The luteinizing hormone receptor [J].
Dufau, ML .
ANNUAL REVIEW OF PHYSIOLOGY, 1998, 60 :461-496
[5]   Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors [J].
Fragoso, MCBV ;
Latronico, C ;
Carvalho, FM ;
Zerbini, MCN ;
Marcondes, JAM ;
Araujo, LMB ;
Lando, VS ;
Frazzatto, ET ;
Mendonca, BB ;
Villares, SMF .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (06) :2074-2078
[6]  
Greulich W.W., 1971, RADIOGRAPHIC ATLAS S
[7]   Involvement of G(s) and G(i) proteins in dual coupling of the luteinizing hormone receptor to adenylyl cyclase and phospholipase C [J].
Herrlich, A ;
Kuhn, B ;
Grosse, R ;
Schmid, A ;
Schultz, G ;
Gudermann, T .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (28) :16764-16772
[8]   GONADOTROPIN-INDEPENDENT PRECOCIOUS PUBERTY [J].
HOLLAND, FJ .
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 1991, 20 (01) :191-210
[9]  
Huseby RA., 1996, LEYDIG CELL, P555
[10]   LEYDIG-CELL TUMORS OF THE TESTIS - A CLINICOPATHOLOGICAL ANALYSIS OF 40 CASES AND REVIEW OF THE LITERATURE [J].
KIM, I ;
YOUNG, RH ;
SCULLY, RE .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1985, 9 (03) :177-192