Cardiovascular protection by alcohol and polyphenols - Role of nitric oxide

被引：19

作者：

Parks, DA

Booyse, FM

机构：

[1] Univ Alabama, Dept Anesthesiol, Birmingham, AL 35233 USA

[2] Univ Alabama, Dept Physiol & Biophys, Birmingham, AL 35233 USA

[3] Univ Alabama, Dept Med, Birmingham, AL 35233 USA

[4] Univ Alabama, Ctr Free Radical Biol, Birmingham, AL 35233 USA

来源：

ALCOHOL AND WINE IN HEALTH AND DISEASE | 2002年 / 957卷

关键词：

nitric oxide; coronary heart disease; nitric oxide synthase; alcohol; red wine;

D O I：

10.1111/j.1749-6632.2002.tb02910.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cardiovascular disease, and in particular coronary heart disease (CHD), remains the leading cause of death in both men and women in the United States. Much epidemiologic evidence indicates that alcoholic beverages, and in particular red Wine, results in a reduction in cardiovascular risk factors and decreases mortality; however, the mechanisms of this cardiovascular protection remains elusive. This review discusses evidence to suggest that (NO)-N-. plays a critical role in cardiovascular protection and that nitric oxide synthase (NOS) is the responsible cardioprotevtive protein (see Bolli et al. 1998. Basic Res. Cardiol. 93: 325-338).

引用

页码：115 / 121

页数：7

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