Valproate-induced hyperammonemic encephalopathy in the presence of topiramate

被引：131

作者：

Hamer, HM ^{[1
]}

Knake, S ^{[1
]}

Schomburg, U ^{[1
]}

Rosenow, F ^{[1
]}

机构：

[1] Univ Marburg, Dept Neurol, D-35033 Marburg, Germany

来源：

NEUROLOGY | 2000年 / 54卷 / 01期

关键词：

valproate; topiramate; adverse effect; ammonia; encephalopathy;

D O I：

10.1212/WNL.54.1.230

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two adult patients with focal epilepsy who tolerated valproate (VPA) well in different combinations of anticonvulsants developed hyperammonemic encephalopathy when treated with VPA in combination with topiramate (TPM). Topiramate may contribute to the increased ammonia level by its inhibition of carbonic anhydrase and cerebral glutamine synthetase, thereby facilitating VPA/TPM hyperammonemic encephalopathy. Recovery occurred after withdrawal of VPA or TPM.

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收藏

页码：230 / 232

页数：3

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