Target-Based Drug Discovery: the Emerging Success of Frontal Affinity Chromatography Coupled to Mass Spectrometry

被引：33

作者：

Calleri, Enrica ^{[1
]}

Temporini, Caterina ^{[1
]}

Caccialanza, Gabriele ^{[1
]}

Massolini, Gabriella ^{[1
]}

机构：

[1] Univ Pavia, Dipartimento Chim Farmaceut, I-27100 Pavia, Italy

来源：

CHEMMEDCHEM | 2009年 / 4卷 / 06期

关键词：

drug discovery; high-throughput screening; binding assays; mass spectrometry; FAC-MS; IMMOBILIZED P-GLYCOPROTEIN; RECEPTOR STATIONARY-PHASE; SMALL-MOLECULE INHIBITORS; TYROSINE KINASE RECEPTOR; LIQUID-CHROMATOGRAPHY; MS DETECTION; SCREENING TECHNIQUES; BINDING AFFINITIES; LEAD GENERATION; FAC-MS;

D O I：

10.1002/cmdc.200800436

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：905 / 916

页数：12

共 46 条

[1] Affinity selection-mass spectrometry screening techniques for small molecule drug discovery [J].

Annis, D. Allen ;

Nickbarg, Elliot ;

Yang, Xianshu ;

Ziebell, Michael R. ;

Whitehurst, Charles E. .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2007, 11 (05) :518-526

[2] G-protein-coupled receptor chromatographic stationary phases.: 2.: Ligand-induced conformational mobility in an immobilized β2-adrenergic receptor [J].

Beigi, F ;

Chakir, K ;

Xiao, RP ;

Wainer, IW .

ANALYTICAL CHEMISTRY, 2004, 76 (24) :7187-7193

[3] Syntheses of immobilized G protein-coupled receptor chromatographic stationary phases:: Characterization of immobilized μ and κ opioid receptors [J].

Beigi, F ;

Wainer, IW .

ANALYTICAL CHEMISTRY, 2003, 75 (17) :4480-4485

[4] Hit and lead generation:: Beyond high-throughput screening [J].

Bleicher, KH ;

Böhm, HJ ;

Müller, K ;

Alanine, AI .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) :369-378

[5]

CHAN N, 2007, MASS SPECTROMETRY ME, pCH6

[6] Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug. discovery: applications of a chromatographic biosensor [J].

Chan, NWC ;

Lewis, DF ;

Rosner, PJ ;

Kelly, MA ;

Schriemer, DC .

ANALYTICAL BIOCHEMISTRY, 2003, 319 (01) :1-12

[7]

Chan NWC, 2002, COMB CHEM HIGH T SCR, V5, P395

[8] The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor [J].

Ciana, Paolo ;

Fumagalli, Marta ;

Trincavelli, Maria Letizia ;

Verderio, Claudia ;

Rosa, Patrizia ;

Lecca, Davide ;

Ferrario, Silvia ;

Parravicini, Chiara ;

Capra, Valerie ;

Gelosa, Paolo ;

Guerrini, Uliano ;

Belcredito, Silvia ;

Cimino, Mauro ;

Sironi, Luigi ;

Tremoli, Elena ;

Rovati, G. Enrico ;

Martini, Claudia ;

Abbracchio, Maria P. .

EMBO JOURNAL, 2006, 25 (19) :4615-4627

[9]

Comess KM, 2004, CURR OPIN DRUG DISC, V7, P411

[10] Applications of mass spectrometry in early stages of target based drug discovery [J].

Deng, GJ ;

Sanyal, G .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 40 (03) :528-538

← 1 2 3 4 5 →