The effects of water extract of Polygonatum odoratum (Mill) Druce on insulin resistance in 90% pancreatectomized rats

被引：4

作者：

Choi, SB

Park, S ^{[1
]}

机构：

[1] Hoseo Univ, Asan 336795, Chungnam Do, South Korea

[2] Konkuk Univ, Chungbuk Do, South Korea

来源：

JOURNAL OF FOOD SCIENCE | 2002年 / 67卷 / 06期

关键词：

Polygonatum Odoratum (Mill) Druce; insulin resistance; glycogen synthase activity; triglycerides; GLUT4;

D O I：

10.1111/j.1365-2621.2002.tb09556.x

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

After administration of 0.3 g Polygonatum Odoratum (Mill) Druce (POD) per 1 kg body weight for 2 mo with a 40% fat diet, serum glucose levels decreased with POD in 90% pancreatectomized (Px) and shamoperated (Sham) rats, compared to placebo (P). Serum insulin concentrations were higher in Sham rats than Px rats. Additionally, compared to P, POD administration decreased serum insulin concentrations in Sham rats, but not in Px rats. Glucose disposal rates in peripheral tissues increased with POD in both Px and Sham rats. Glycogen deposits, GLUT4 contents, and fraction velocity of glycogen synthase in soleus muscle increased with POD administration in Px and Sham rats. In conclusion, POD ameliorates insulin resistance by enhancing glucose utilization in muscle.

引用

页码：2375 / 2379

页数：5

共 28 条

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[2] PARTIAL PANCREATECTOMY IN THE RAT AND SUBSEQUENT DEFECT IN GLUCOSE-INDUCED INSULIN RELEASE [J].