Acute coronary syndrome - Biochemical strategies in the troponin era

被引:48
作者
Panteghini, M [1 ]
机构
[1] Spedali Civil Brescia, Azienda Osped, Lab Anal Chim Clin 1, I-25125 Brescia, Italy
关键词
emergency medicine; laboratory diagnosis; myocardial infarction; myoglobin; troponin;
D O I
10.1378/chest.122.4.1428
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
New biomarkers, such as cardiac troponins, have a major role to play for cost-effective management of individuals with acute chest pain and suspected coronary syndrome, and the laboratory is now poised to assume a vital role in assessing damage and determining prognosis. The redefined biochemical criterion proposed to classify acute coronary syndrome patients presenting with ischemic symptoms as patients with myocardial infarction is heavily predicated on an increased troponin concentration in blood. in an era of evidence-based medicine, we can no longer overlook the diagnostic and prognostic benefits provided by the measurement of these highly sensitive and specific proteins.
引用
收藏
页码:1428 / 1435
页数:8
相关论文
共 69 条
[1]   Myocardial infarction redefined -: A consensus Document of the Joint European Society of Cardiology/American College of Cardiology Committee for the Redefinition of Myocardial Infarction [J].
Alpert, JS ;
Antman, E ;
Apple, F ;
Armstrong, PW ;
Bassand, JP ;
de Luna, AB ;
Beller, G ;
Breithardt, G ;
Chaitman, BR ;
Clemmensen, P ;
Falk, E ;
Fishbein, MC ;
Galvani, M ;
Garson, A ;
Grines, C ;
Hamm, C ;
Jaffe, A ;
Katus, H ;
Kjekshus, J ;
Klein, W ;
Klootwijk, P ;
Lenfant, C ;
Levy, D ;
Levy, RI ;
Luepker, R ;
Marcus, F ;
Näslund, U ;
Ohman, M ;
Pahlm, O ;
Poole-Wilson, P ;
Popp, R ;
Alto, P ;
Pyörälä, K ;
Ravkilde, J ;
Rehnquist, N ;
Roberts, W ;
Roberts, R ;
Roelandt, J ;
Rydén, L ;
Sans, S ;
Simoons, ML ;
Thygesen, K ;
Tunstall-Pedoe, H ;
Underwood, R ;
Uretsky, BF ;
Van de Werf, F ;
Voipio-Pulkki, LM ;
Wagner, G ;
Wallentin, L ;
Wijns, W .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (03) :959-969
[2]  
Altinier S, 2000, CLIN CHEM, V46, P991
[3]  
[Anonymous], 1979, Circulation, V59, P607
[4]   Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes [J].
Antman, EM ;
Tanasijevic, MJ ;
Thompson, B ;
Schactman, M ;
McCabe, CH ;
Cannon, CP ;
Fischer, GA ;
Fung, AY ;
Thompson, C ;
Wybenga, D ;
Braunwald, E .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (18) :1342-1349
[5]  
Apple FS, 2000, CLIN CHEM, V46, P1604
[6]  
Apple FS, 2000, CLIN CHEM, V46, P572
[7]  
Apple FS, 1999, CLIN CHEM, V45, P206
[8]  
Apple FS, 1999, CLIN CHEM, V45, P18
[9]  
Apple FS, 2001, CLIN CHEM, V47, P587
[10]  
Apple FS, 2001, CLIN CHEM, V47, P377