Retinal glial cell responses and Fas/FasL activation in rats with chronic ocular hypertension

被引：52

作者：

Ju, Kwany Ro ^{[1
]}

Kim, Hwa Sun ^{[1
]}

Kim, Jie Hyun ^{[1
]}

Lee, Na Young ^{[1
]}

Park, Chan Kee ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Ophthalmol, Seoul 137701, South Korea

来源：

BRAIN RESEARCH | 2006年 / 1122卷

关键词：

apoptosis; retinal ganglion cell; retinal glia; Fas/FasL; glaucoma;

D O I：

10.1016/j.brainres.2006.09.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Responses in the retina post injury provoke glial reactions that are not completely understood. This study investigated the reaction of retinal glial cells and the expression and localization of the Fas and Fas-ligand (FasL) in rats with chronic ocular hypertension. Experimental glaucoma was induced in one eye of 60 Sprague-Dawley rats by cauterizing three episcleral vessels. It caused a moderate intraocular pressure (IOP) elevation and significant retinal ganglion cell (RGC) loss for at least 6 weeks in all animals. Immunohistochemical analysis revealed that the expression of GFAP and OX-42 increased in the injured retinae. Fas/FasL immunoreactivity was elevated in the microglia, and we also observed an incremental increase in Fas associated death domain (FADD) immunore activity in Milller glial cells and RGCs in the IOP-elevated retinae. The activation of glial cells and upregulation of Fas and FasL suggest that glial cells may contribute to Fas-mediated cell death in the neuro degeneration process of chronic ocular hypertensive retinal insult. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：209 / 221

页数：13

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