The Transcriptional Corepressor CtBP: A Foe of Multiple Tumor Suppressors

被引：203

作者：

Chinnadurai, G. ^{[1
]}

机构：

[1] St Louis Univ, Hlth Sci Ctr, Inst Mol Virol, Doisy Res Ctr, St Louis, MO 63104 USA

来源：

CANCER RESEARCH | 2009年 / 69卷 / 03期

关键词：

TERMINAL-BINDING-PROTEIN; BETA-CATENIN; CELLULAR PHOSPHOPROTEIN; MESENCHYMAL TRANSITION; REGULATES EXPRESSION; NEGATIVE MODULATION; E1A PROTEIN; CELLS; CANCER; TRANSFORMATION;

D O I：

10.1158/0008-5472.CAN-08-3349

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

CtBP1 and CtBP2 are closely related and evolutionarily conserved transcriptional corepressors. There is strong evidence linking CtBPs to tumorigenesis and tumor progression. CtBPs promote epithelial-mesenchymal transition and function as apoptosis antagonists. Also, CtBPs mediate repression of several tumor suppressor genes. Certain tumor suppressors also target CtBPs to restrain their tumor-promoting activity. Down-regulation of CtBPs mediated by some tumor suppressors results in p53-independent apoptosis and reduced tumor cell migration and invasion. The role of CtBPs in modulating the activities of different tumor suppressors is reviewed here. The results discussed here suggest that CtBPs may constitute a novel p53-independent anticancer target. [Cancer Res 2009;69(3):731-4]

引用

页码：731 / 734

页数：4

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