Myofibroblasts and mechano-regulation of connective tissue remodelling

被引：3273

作者：

Tomasek, JJ

Gabbiani, G

Hinz, B

Chaponnier, C

Brown, RA

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Cell Biol, Oklahoma City, OK 73190 USA

[2] Univ Geneva, Ctr Med Univ, Dept Pathol, CH-1211 Geneva 4, Switzerland

[3] UCL, Inst Orthopaed, Royal Natl Orthopaed Hosp, Tissue Repair Engn Ctr, Stanmore HA7 4LP, Middx, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2002年 / 3卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm809

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During the past 20 years, it has become generally accepted that the modulation of fibroblastic cells towards the myofibroblastic phenotype, with acquisition of specialized contractile features, is essential for connective-tissue remodelling during normal and pathological wound healing. Yet the myofibroblast still remains one of the most enigmatic of cells, not least owing to its transient appearance in association with connective-tissue injury and to the difficulties in establishing its role in the production of tissue contracture. It is clear that our understanding of the myofibroblast - its origins, functions and molecular regulation - will have a profound influence on the future effectiveness not only of tissue engineering but also of regenerative medicine generally.

引用

页码：349 / 363

页数：15

共 151 条

[1]

ABERCROMBIE M, 1956, J EMBRYOL EXP MORPH, V4, P167

[2] Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase [J].