GLP-1 nanomedicine alleviates gut inflammation

被引：68

作者：

Anbazhagan, Arivarasu N. ^{[1
]}

Thaqi, Mentor ^{[2
]}

Priyamvada, Shubha ^{[1
]}

Jayawardena, Dulari ^{[2
]}

Kumar, Anoop ^{[1
]}

Gujral, Tarunmeet ^{[1
]}

Chatterjee, Ishita ^{[1
]}

Mugarza, Edurne ^{[1
]}

Saksena, Seema ^{[1
]}

Onyuksel, Hayat ^{[2
]}

Dudeja, Pradeep K. ^{[1
,3
]}

机构：

[1] Univ Illinois, Coll Med, Div Gastroenterol & Hepatol, Dept Med, Chicago, IL USA

[2] Univ Illinois, Coll Pharm, Dept Biopharmaceut Sci, Chicago, IL USA

[3] Jesse Brown VA Med Ctr, Chicago, IL USA

来源：

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE | 2017年 / 13卷 / 02期

基金：

美国国家卫生研究院;

关键词：

GLP-1; SSM; Diarrhea; IBD; Colitis; RECEPTOR; COLITIS; DISEASE; SUSCEPTIBILITY; INHIBITION; MECHANISMS; EXPRESSION; PHYSIOLOGY; INJURY; CELLS;

D O I：

10.1016/j.nano.2016.08.004

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

The gut hormone, glucagon like peptide-1 (GLP-1) exerts anti-inflammatory effects. However, its clinical use is limited by its short half-life. Previously, we have shown that GLP-1 as a nanomedicine (GLP-1 in sterically stabilized phospholipid micelles, GLP-1-SSM) has increased in vivo stability. The current study was aimed at testing the efficacy of this GLP-1 nanomedicine in alleviating colonic inflammation and associated diarrhea in dextran sodium sulfate (DSS) induced mouse colitis model. Our results show that GLP-1-SSM treatment markedly alleviated the colitis phenotype by reducing the expression of pro-inflammatory cytokine IL-1 beta, increasing goblet cells and preserving intestinal epithelial architecture in colitis model. Further, GLP-1-SSM alleviated diarrhea (as assessed by luminal fluid) by increasing protein expression of intestinal chloride transporter DRA (down regulated in adenoma). Our results indicate thatGLP-1 nanomedicine may act as a novel therapeutic tool in alleviating gut inflammation and associated diarrhea in inflammatory bowel disease (IBD). Published by Elsevier Inc.

引用

页码：659 / 665

页数：7

共 30 条

[1]

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population [J].

Asano, Kouichi ;

Matsushita, Tomonaga ;

Umeno, Junji ;

Hosono, Naoya ;

Takahashi, Atsushi ;

Kawaguchi, Takahisa ;

Matsumoto, Takayuki ;

Matsui, Toshiyuki ;

Kakuta, Yoichi ;

Kinouchi, Yoshitaka ;

Shimosegawa, Tooru ;

Hosokawa, Masayo ;

Arimura, Yoshiaki ;

Shinomura, Yasuhisa ;

Kiyohara, Yutaka ;

Tsunoda, Tatsuhiko ;

Kamatani, Naoyuki ;

Iida, Mitsuo ;

Nakamura, Yusuke ;

Kubo, Michiaki .

NATURE GENETICS, 2009, 41 (12) :1325-U92

[2]

Pharmacology, Physiology, and Mechanisms of Incretin Hormone Action [J].

Campbell, Jonathan E. ;

Drucker, Daniel J. .

CELL METABOLISM, 2013, 17 (06) :819-837

[3]

Chen Sheng, 2014, Dermatol Pract Concept, V4, P23, DOI 10.5826/dpc.0402a04

[4]

Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn's disease and ulcerative colitis [J].

Chouliaras, Giorgos ;

Panayotou, Ioanna ;

Margoni, Daphne ;

Mantzou, Emilia ;

Pervanidou, Panagiota ;

Manios, Yannis ;

Chrousos, George P. ;

Roma, Eleftheria .

PEDIATRIC RESEARCH, 2013, 74 (04) :420-426

[5]

Inflammatory bowel disease [J].

Corridoni, Daniele ;

Arseneau, Kristen O. ;

Cominelli, Fabio .

IMMUNOLOGY LETTERS, 2014, 161 (02) :231-235

[6]

DPP-4 Inhibitors Repress NLRP3 Inflammasome and Interleukin-1beta via GLP-1 Receptor in Macrophages Through Protein Kinase C Pathway [J].

Dai, Yao ;

Dai, Dongsheng ;

Wang, Xianwei ;

Ding, Zufeng ;

Mehta, Jawahar L. .

CARDIOVASCULAR DRUGS AND THERAPY, 2014, 28 (05) :425-432

[7]

JNK3 Is Required for the Cytoprotective Effect of Exendin 4 [J].

Ezanno, Helene ;

Pawlowski, Valerie ;

Abdelli, Saida ;

Boutry, Raphael ;

Gmyr, Valery ;

Kerr-Conte, Julie ;

Bonny, Christophe ;

Pattou, Francois ;

Abderrahmani, Amar .

JOURNAL OF DIABETES RESEARCH, 2014, 2014

[8]

Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis [J].

Hogan, A. E. ;

Tobin, A. M. ;

Ahern, T. ;

Corrigan, M. A. ;

Gaoatswe, G. ;

Jackson, R. ;

O'Reilly, V. ;

Lynch, L. ;

Doherty, D. G. ;

Moynagh, P. N. ;

Kirby, B. ;

O'Connell, J. ;

O'Shea, D. .

DIABETOLOGIA, 2011, 54 (11) :2745-2754

[9]

The physiology of glucagon-like peptide 1 [J].

Holst, Jens Juul .

PHYSIOLOGICAL REVIEWS, 2007, 87 (04) :1409-1439

[10]

CD26/DPP-4 inhibition recruits regenerative stem cells via stromal cell-derived factor-1 and beneficially influences ischaemia-reperfusion injury in mouse lung transplantation [J].

Jungraithmayr, Wolfgang ;

De Meester, Ingrid ;

Matheeussen, Veerle ;

Baerts, Lesley ;

Arni, Stephan ;

Weder, Walter .

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 2012, 41 (05) :1166-1173

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