Enantioselective adsorption of ibuprofen and lysine in metal-organic frameworks

被引：51

作者：

Bueno-Perez, Rocio ^{[1
]}

Martin-Calvo, Ana ^{[1
]}

Gomez-Alvarez, Paula ^{[1
]}

Gutierrez-Sevillano, Juan J. ^{[2
]}

Merkling, Patrick J. ^{[1
]}

Vlugt, Thijs J. H. ^{[2
]}

van Erp, Titus S. ^{[3
]}

Dubbeldam, David ^{[4
]}

Calero, Sofia ^{[1
]}

机构：

[1] Univ Pablo Olavide, Seville 41013, Spain

[2] Delft Univ Technol, Proc Energy Dept, NL-2628 CB Delft, Netherlands

[3] Norwegian Univ Sci & Technol, Dept Chem, N-7941 Trondheim, Norway

[4] Univ Amsterdam, NL-1098 XH Amsterdam, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 74期

基金：

欧洲研究理事会;

关键词：

FORCE-FIELD; CHIRAL RECOGNITION; ACHIRAL ZEOLITES; DRUG-DELIVERY; SIMULATIONS; PERFORMANCE; SEPARATION; ENANTIOMERS; RESOLUTION; DYNAMICS;

D O I：

10.1039/c4cc03745f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

引用

页码：10849 / 10852

页数：4

共 32 条

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[Anonymous], PROTEINS STRUCT FUNC

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