Dermatitis herpetiformis and celiac disease are both primarily associated with the HLA-DQ (alpha 10501,beta 102) or the HLA-DQ (alpha 103,beta 10302) heterodimers

被引：101

作者：

Spurkland, A ^{[1
]}

Ingvarsson, G ^{[1
]}

Falk, ES ^{[1
]}

Knutsen, I ^{[1
]}

Sollid, LM ^{[1
]}

Thorsby, E ^{[1
]}

机构：

[1] UNIV HOSP,DEPT DERMATOL,TROMSO,NORWAY

来源：

TISSUE ANTIGENS | 1997年 / 49卷 / 01期

关键词：

dermatitis herpetiformis; celiac disease;

D O I：

10.1111/j.1399-0039.1997.tb02706.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HLA-DRB1, -DQA1, and -DQB1 genomic typing of 50 patients with dermatitis herpetiformis and of 290 healthy blood donors was performed. Genes encoding the DQ (alpha 1*0501, beta 1*02) heterodimer were carried by 43 (86%) of the patients and 72 (25%) of the controls. Of the remaining seven patients six (12% of all the patients) carried genes encoding the DQ (alpha 1*03, beta 1*0302) heterodimer. These HLA associations are very similar to those observed in patients with celiac disease. We thus conclude that dermatitis herpetiformis and celiac disease are associated to the very same HLA-DQ alpha beta heterodimers.

引用

页码：29 / 34

页数：6

共 29 条

[1] MAJOR HISTOCOMPATIBILITY COMPLEX SUSCEPTIBILITY GENES FOR DERMATITIS-HERPETIFORMIS COMPARED WITH THOSE FOR GLUTEN-SENSITIVE ENTEROPATHY [J].