Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer

被引：672

作者：

Nilsson, J. ^{[1
,2
]}

Skog, J. ^{[3
,4
,5
]}

Nordstrand, A. ^{[2
]}

Baranov, V. ^{[6
]}

Mincheva-Nilsson, L. ^{[6
]}

Breakefield, X. O. ^{[3
,4
,5
]}

Widmark, A. ^{[2
]}

机构：

[1] VU Med Ctr, Canc Ctr Amsterdam, Neurooncol Res Grp, Dept Neurosurg, Amsterdam, Netherlands

[2] Umea Univ, Dept Radiat Sci, Umea, Sweden

[3] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[5] Harvard Univ, Sch Med, Neurosci Program, Boston, MA 02115 USA

[6] Umea Univ, Dept Clin Immunol, Umea, Sweden

来源：

BRITISH JOURNAL OF CANCER | 2009年 / 100卷 / 10期

关键词：

prostate cancer; prostasomes; tumour exosomes; biomarkers; PROMOTE TUMOR-GROWTH; DIAGNOSTIC BIOMARKERS; FUSION; GENE; SEDIMENTS; ANTIGEN; TMPRSS2; PCA3;

D O I：

10.1038/sj.bjc.6605058

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2: ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status. British Journal of Cancer ( 2009) 100, 1603-1607. doi: 10.1038/sj.bjc.6605058 www.bjcancer.com Published online 28 April 2009 (C) 2009 Cancer Research UK

引用

页码：1603 / 1607

页数：5

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