Optic neuropathy in cancer patients. Report of a case possibly related to 5 fluorouracil toxicity and review of the literature

被引：31

作者：

Delval, L

Klastersky, J

机构：

[1] Free Univ Brussels, Ctr Tumeurs, Serv Med Interne, Brussels, Belgium

[2] Free Univ Brussels, Ctr Tumeurs, Clin Invest Lab, Brussels, Belgium

来源：

JOURNAL OF NEURO-ONCOLOGY | 2002年 / 60卷 / 02期

关键词：

breast cancer; dihydropyrimidine dehydrogenase deficiency; fluorouracil toxicity; paraneoplastic neurologic syndrome; optic neuropathy;

D O I：

10.1023/A:1020613600826

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the case of a 72-year-old woman suffering from bone metastatic breast cancer and treated with continuous intravenous 5 fluorouracil (5FU) chemotherapy, who presented with a bilateral asymmetric anterior optic neuropathy (ON). A deficiency of dihydropyrimidine dehydrogenase (DPD) was documented. Patients with DPD deficiency are at increased risk for developing unusual and/or severe toxicity to 5FU. We discuss the differential diagnosis of anterior ON and we suggest that 5FU can be responsible for optic nerve toxicity in patients with DPD deficiency.

引用

页码：165 / 169

页数：5

共 35 条

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[2]

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