Serum S100β increases in marathon runners reflect extracranial release rather than glial damage

被引：93

作者：

Hasselblatt, M

Mooren, FC

von Ahsen, N

Keyvani, K

Fromme, A

Schwarze-Eicker, K

Senner, V

Paulus, W

机构：

[1] Univ Hosp Munster, Inst Neuropathol, D-48129 Munster, Germany

[2] Univ Hosp Munster, Inst Sports Med, D-48129 Munster, Germany

[3] Univ Gottingen, Dept Clin Chem, D-3400 Gottingen, Germany

来源：

NEUROLOGY | 2004年 / 62卷 / 09期

关键词：

D O I：

10.1212/01.WNL.0000123092.97047.B1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The contribution of extracranial tissue damage to serum S100beta increases was examined in 18 marathon runners without clinical or laboratory signs of brain damage. Postrace serum S100beta and creatine kinase (CK) concentrations increased (p < 0.001), and areas under the curve were highly correlated (p = 0.001). To conclude, serum S100 beta increases after running originate from extracranial sources. CK determination may improve specificity of S100 beta as a marker of brain tissue damage in acute trauma.

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页码：1634 / 1636

页数：3

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