Nitric oxide enhances cytotoxicity of cultured rabbit gastric mucosal cells induced by hydrogen peroxide

被引：17

作者：

Hata, Y

Ota, S

Hiraishi, H

Terano, A

Ivey, KJ

机构：

[1] VET AFFAIRS MED CTR,DEPT MED,LONG BEACH,CA

[2] UNIV CALIF IRVINE,IRVINE,CA 92717

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1996年 / 1290卷 / 03期

关键词：

nitric oxide; hydrogen peroxide; reactive oxygen metabolite; gastric cytoprotection; mucous glycoprotein; prostaglandin E(2); (rabbit gastric mucosal cell);

D O I：

10.1016/0304-4165(96)00024-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

While NO has been reported to act as a protective factor to gastric mucosa, it has been shown to be cytotoxic to various cells. NO also has been demonstrated to stimulate prostaglandin (PG) release and mucous glycoprotein secretion which could result in the activation of gastric defensive mechanisms. We examined the effect of NO on cytotoxicity induced by hydrogen peroxide, and mucous glycoprotein secretion and PGE(2) release from cultured rabbit gastric mucosal cells. NO enhanced cytotoxicity induced by hydrogen peroxide. Defensive prostaglandin E(2) release and mucous glycoprotein secretion were not altered by NO. Under certain circumstances, NO might behave as an aggressive factor in gastric mucosal injury.

引用

页码：257 / 260

页数：4

共 22 条

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